Type 2 deiodinase polymorphism (threonine 92 alanine) predicts L-thyroxine dose to achieve target thyrotropin levels in thyroidectomized patients.

@article{Torlontano2008Type2D,
  title={Type 2 deiodinase polymorphism (threonine 92 alanine) predicts L-thyroxine dose to achieve target thyrotropin levels in thyroidectomized patients.},
  author={Massimo Torlontano and Cosimo Durante and Isabella Torrente and Umberto Crocetti and Giovanni Augello and Giuseppe Ronga and Teresa Montesano and Laura Travascio and Antonella Verrienti and Rocco Bruno and Stefano Santini and Palmina D'Arcangelo and Bruno Dallapiccola and Sebastiano Filetti and Vincenzo Trischitta},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2008},
  volume={93 3},
  pages={910-3}
}
CONTEXT Type 2 deiodinase (D2) converts T4 in T3 in several human tissues, including hypothalamus and pituitary, and, therefore, plays a pivotal role in the negative feedback regulation of TSH secretion. A common variant of the gene, threonine (Thr) 92 alanine (Ala), has been identified and associated with decreased D2 enzymatic activity. OBJECTIVE Our objective was to investigate whether this polymorphism predicts the T4 dosage needed to obtain target TSH levels in thyroidectomized patients… CONTINUE READING

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