Type 2 deiodinase Thr92Ala polymorphism impact on clinical course and myocardial remodeling in patients with Graves' disease.

@article{Grineva2009Type2D,
  title={Type 2 deiodinase Thr92Ala polymorphism impact on clinical course and myocardial remodeling in patients with Graves' disease.},
  author={Elena N Grineva and Alina Yu Babenko and Natalya V Vahrameeva and M. Bogdanova and Anna Kostareva and Daria Popcova and Valentina I Larionova},
  journal={Cell cycle},
  year={2009},
  volume={8 16},
  pages={2565-9}
}
Patients with thyreotoxicosis have variable clinical manifestations and various degree of cardiomyopathy which severity depends on many factors. Last years the genetic factors predicting development and clinical features of thyrotoxic symptoms and thyreotoxic cardiomyopathy became more evident. It is known, that production of T3 in various tissues including cardiac muscle is limited by deiodinase 2 (D2). Recent studies showed that certain polymorphisms, including Thr92Ala of D2 gene, are… CONTINUE READING

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