Type 2 cytotoxic T lymphocytes modulate the activity of dendritic cells toward type 2 immune responses.

@article{Iezzi2006Type2C,
  title={Type 2 cytotoxic T lymphocytes modulate the activity of dendritic cells toward type 2 immune responses.},
  author={Giandomenica Iezzi and Andrea Boni and Elena Degl'Innocenti and Matteo Grioni and Maria Teresa Sabrina Bertilaccio and Matteo Bellone},
  journal={Journal of immunology},
  year={2006},
  volume={177 4},
  pages={2131-7}
}
Activated CD8+ T cells can differentiate into type 1 (Tc1) cells, producing mainly IFN-gamma, and type 2 (Tc2) cells, producing mostly IL-4, IL-5, and IL-10. Tc1 cells are potent CTL involved in the defense against intracellular pathogens and cancer cells. The role of Tc2 cells in the immune response is largely unknown, although their presence in chronic infections, cancer, and autoimmune diseases is associated with disease severity and progression. Here, we show that mouse Tc2 cells modify… CONTINUE READING

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