Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis.

  title={Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis.},
  author={Geok Teng Seah and Gillian Marie Scott and Graham A. W. Rook},
  journal={The Journal of infectious diseases},
  volume={181 1},
The extent of type 2 cytokine gene expression in patients with pulmonary tuberculosis (TB) was studied by use of quantitative nested reverse-transcription polymerase chain reaction on freshly isolated peripheral blood mononuclear cells. Interleukin (IL)-4 and IL-13 mRNA expression was significantly greater in patients-median mRNA copy numbers were 1.7 and 1.1 log10 higher, respectively-than in matched tuberculin-positive control subjects. Significant correlations with radiologic extent of… CONTINUE READING


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