Type 1A diabetes mellitus-associated autoimmunity.

  title={Type 1A diabetes mellitus-associated autoimmunity.},
  author={Edwin Liu and George S. Eisenbarth},
  journal={Endocrinology and metabolism clinics of North America},
  volume={31 2},
  pages={391-410, vii-viii}
Type 1A diabetes mellitus has become one of the most intensively studied autoimmune disorders, with characterized animal models and extensive prospective studies of the development of anti-islet autoimmunity. It is now possible to predict the development of type 1A diabetes mellitus, beginning with HLA-encoded genetic susceptibility, followed by the development of a series of anti-islet autoantibodies. Prediction primarily is based on the detection of multiple anti-islet autoantibodies reacting… CONTINUE READING