Type 17 T helper cells—origins, features and possible roles in rheumatic disease

@article{Annunziato2009Type1T,
  title={Type 17 T helper cells—origins, features and possible roles in rheumatic disease},
  author={Francesco Annunziato and Lorenzo Cosmi and F Leonarda Liotta and Enrico Maggi and Sergio Romagnani},
  journal={Nature Reviews Rheumatology},
  year={2009},
  volume={5},
  pages={325-331}
}
Type 17 T helper (TH17) cells are a population of CD4+ effector T cells that are distinct from TH1 and TH2 cells owing to their ability to produce interleukin (IL)-17. Although TH1 and TH2 cells are similar in mice and humans, TH17 cells differ in several ways. The differentiation of mouse TH17 cells requires transforming growth factor β and IL-6, whereas human naive T cells can develop into TH17 cells in the presence of IL-1β and IL-23 alone, transforming growth factor β having an indirect… CONTINUE READING

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