Type 1 plasminogen activator inhibitor synthesis of endothelial cells is downregulated by smooth muscle cells.

@article{Christ1993Type1P,
  title={Type 1 plasminogen activator inhibitor synthesis of endothelial cells is downregulated by smooth muscle cells.},
  author={Gunter Christ and Dietmar Seiffert and Peter Hufnagl and Alois W. Gessl and Johann Wojta and Bernd R. Binder},
  journal={Blood},
  year={1993},
  volume={81 5},
  pages={1277-83}
}
Plasminogen activator inhibitor type 1 (PAI-1), the physiologic inhibitor of both tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), is a major biosynthetic product of endothelial cells in vitro; endothelial cells in vivo, in contrast, do not appear to produce significant amounts of PAI-1 as made evident by in situ-hybridization studies in normal mice. This suggests that the high rate of PAI-1 synthesis of endothelial cells in vitro might be a result of the… CONTINUE READING

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References

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Showing 1-10 of 56 references

Endotoxin induces the expression of type 1 plasminogen activator inhibitor (PAI1) protein and mRNA by endothelial cells in mouse tissue in vivo

Y I . Eguchi, M Keeton, M Sawdey, DJ Loskutoff
Thromb. Haemostas • 1991

Character - ization of the activation of latent TGF( 3 by cocultures of endothelial cells and pericytes or smooth muscle cells : A self - regulating system

R Tsuboi, R Lyons, H Moses, DB Rifkin
J Cell Biol I • 1990

DB: Characterization of the activation of latent TGF-(3 by co-cultures of endothelial cells and pericytes or smooth muscle cells: A self-regulating system

R Tsuboi, R Lyons, H Moses, Rifkin
J Cell Biol I • 1990

In vivo localization of type 1 plasminogen activator inhibitor ( PAII ) using in situ hybridization

N Keeton, M Nguyen, DJ Loskutoff
Fibrinolysis • 1990

Loskutoff DJ: In vivo localization of type 1 plasminogen activator inhibitor (PAI-I) using in situ hybridization

N Keeton, M Nguyen
Fibrinolysis 4:52a, • 1990

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