Type-1 insulin-like growth factor receptor overexpression produces dual effects on myoblast proliferation and differentiation.

@article{Quinn1994Type1IG,
  title={Type-1 insulin-like growth factor receptor overexpression produces dual effects on myoblast proliferation and differentiation.},
  author={Lebris S Quinn and Bernhard G Steinmetz and Alex Maas and Leelee Ong and Michael Kaleko},
  journal={Journal of cellular physiology},
  year={1994},
  volume={159 3},
  pages={387-98}
}
Using a retroviral vector, we developed a line of C2 mouse skeletal myoblasts, C2-LISN, which expressed high levels of the human type-1 insulin-like growth factor (IGF) receptor. When switched to low serum medium, C2-LISN myoblasts underwent terminal differentiation extremely rapidly compared to control C2 myoblasts. In high serum conditions which were not permissive for differentiation, C2-LISN myoblasts expressed ten-fold higher levels of the myogenic transcription factor myogenin than did… CONTINUE READING