Type 1 fimbrial adhesin FimH elicits an immune response that enhances cell adhesion of Escherichia coli.

@article{Tchesnokova2011Type1F,
  title={Type 1 fimbrial adhesin FimH elicits an immune response that enhances cell adhesion of Escherichia coli.},
  author={Veronika L Tchesnokova and Pavel Aprikian and Dagmara I Kisiela and Sarah Gowey and Natalia Korotkova and Wendy Thomas and Evgeni V. Sokurenko},
  journal={Infection and immunity},
  year={2011},
  volume={79 10},
  pages={3895-904}
}
Escherichia coli causes about 90% of urinary tract infections (UTI), and more than 95% of all UTI-causing E. coli express type 1 fimbriae. The fimbrial tip-positioned adhesive protein FimH utilizes a shear force-enhanced, so-called catch-bond mechanism of interaction with its receptor, mannose, where the lectin domain of FimH shifts from a low- to a high-affinity conformation upon separation from the anchoring pilin domain. Here, we show that immunization with the lectin domain induces… CONTINUE READING
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