Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapy.

@article{Park2008Type1D,
  title={Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapy.},
  author={Jean Y Park and Angeline Y. Chong and Elaine K. Cochran and David E Kleiner and Michael J Haller and Desmond A Schatz and Phillip Gorden},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2008},
  volume={93 1},
  pages={
          26-31
        }
}
CONTEXT Acquired generalized lipodystrophy (AGL) is marked by severe insulin resistance and hypertriglyceridemia. Rarely, AGL and type 1 diabetes (T1D) coexist. OBJECTIVE Our objective was to describe the response to leptin therapy in patients with coexisting AGL and T1D and to document the autoimmune diseases associated with AGL. DESIGN AND SETTING We conducted an open-label prospective study at the Clinical Research Center of the National Institutes of Health. PATIENTS Participants… CONTINUE READING
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