Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.

@article{Garg2012Type1D,
  title={Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.},
  author={Garima Garg and Jennifer R Tyler and Jennie H M Yang and Antony J Cutler and Kate Downes and Marcin Pekalski and Gwynneth L. Bell and Sarah Nutland and Mark Peakman and John A. Todd and Linda S. Wicker and Timothy I M Tree},
  journal={Journal of immunology},
  year={2012},
  volume={188 9},
  pages={
          4644-53
        }
}
Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1 diabetes, are deficient in their ability to control autologous proinflammatory responses when compared with nondiseased, control individuals. Treg dysfunction could be a primary, causal event or may result from perturbations in the immune system during disease development. Polymorphisms in genes associated with Treg function, such as IL2RA… CONTINUE READING

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