Type 1 diabetes

@article{Daneman2006Type1D,
  title={Type 1 diabetes},
  author={Denis Daneman},
  journal={The Lancet},
  year={2006},
  volume={367},
  pages={847-858}
}
  • D. Daneman
  • Published 11 March 2006
  • Medicine
  • The Lancet
View on Elsevier
ghr.nlm.nih.gov
548 Citations
Highly Influential Citations
35
Background Citations
228
Methods Citations
7
Results Citations
2

Tables from this paper

548 Citations

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Autoimmune diabetes in adults : epidemiological studies of risk factors and mortality

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The results are in line with previous data indicating that the aetiology of autoimmune diabetes is partly similar to that of type 2 diabetes but suggest, also, that there are other, currently unidentified, environmental risk factors for autoimmune diabetes that remain to be explored.

Microvascular disease in children and adolescents with type 1 diabetes and obesity

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This chapter gives the knowledge about diabetes mechanism of drug resistance, classification, pathophysiology and its management and further research is needed to be done in order to prevent the world from this widespread disease.

Clinical Management of the Physically Active Patient with Type 1 Diabetes

TLDR
Challenges and key strategies for diabetes management in the active individual with type 1 diabetes are highlighted, including the application of the most recent diabetes technologies.

Progress in the Development of Immune-Based Therapies for Type 1 Diabetes Mellitus

TLDR
A wide variety of immuno-interventions cure T1DM effectively in different animal models when given early in disease development but few of these interventions are efficacious in humans at a later stage of the disease.
...

References

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Type 1 diabetes: recent developments

TLDR
This review focuses here on recent advances in the understanding of the epidemiology, pathogenesis, prediction, prevention, and prevention of type 1 diabetes and new treatments for the disease.

Type 2 diabetes: principles of pathogenesis and therapy

Early Diabetes-Related Complications in Adolescents

  • D. Daneman
  • Medicine
    Hormone Research in Paediatrics
  • 2005
TLDR
The literature that underpins the available guidelines and stresses the pivotal role of excellent metabolic control in complication prevention is reviewed.

Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus.

TLDR
The DCCT proved that intensive treatment reduced the risks of retinopathy, nephropathy, and neuropathy by 35% to 90% compared with conventional treatment, and the benefits of 6.5 years of intensive treatment extend well beyond the period of its most intensive implementation.

Early vascular risk factor modification in type 1 diabetes.

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Large-scale studies defined the natural history of the development of early retinal lesions and their progression to loss of vision, leading to interventions such as laser-photocoagulation therapy to help prevent vision loss.

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long‐Term Complications in Insulin‐Dependent Diabetes Mellitus

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Intensive therapy effectively delays the onset and slows the progression of diabetic retinopathy, nephropathy, and neuropathy in patients with IDDM.

Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study.

TLDR
The persistent beneficial effects on albumin excretion and the reduced incidence of hypertension 7 to 8 years after the end of the D CCT suggest that previous intensive treatment of diabetes with near-normal glycemia during the DCCT has an extended benefit in delaying progression of diabetic nephropathy.

Antihypertensive treatment and multifactorial approach for renal protection in diabetes.

TLDR
A target-driven, long-term, intensified intervention aimed at multiple risk factors should be recommended in patients with diabetes to preserve their kidney function.

Agents in development for the treatment of diabetic nephropathy

TLDR
It is anticipated that additional thera-peutic approaches that inhibit both metabolic and haemodynamic pathways will include strategies that target growth factors, cytokines and intracellular second messengers, which are expected to lead to improved therapies for the treatment of diabetic nephropathy.

Current knowledge of Japanese type 1 diabetic syndrome

The Japanese have one of the lowest incidence of childhood type 1 diabetes in the world, but the incidence of this disease is clearly increasing within the Japanese population, as reported in several…
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