Type 1 diabetes: translating mechanistic observations into effective clinical outcomes

  title={Type 1 diabetes: translating mechanistic observations into effective clinical outcomes},
  author={Kevan C Herold and Dario A A Vignali and Anne Cooke and Jeffrey A Bluestone},
  journal={Nature Reviews Immunology},
Type 1 diabetes (T1D) remains an important health problem, particularly in western countries, where the incidence has been increasing in younger children. In 1986, Eisenbarth described T1D as a chronic autoimmune disease. Work over the past three-and-a-half decades has identified many of the genetic, immunological and environmental factors that are involved in the disease and have led to hypotheses concerning its pathogenesis. Clinical trials have been conducted to test these hypotheses but… CONTINUE READING
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  • L.
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  • 2012

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