Type 1 Fimbriae, a Colonization Factor of Uropathogenic Escherichia coli, Are Controlled by the Metabolic Sensor CRP-cAMP

@article{Mller2009Type1F,
  title={Type 1 Fimbriae, a Colonization Factor of Uropathogenic Escherichia coli, Are Controlled by the Metabolic Sensor CRP-cAMP},
  author={Claudia M. M{\"u}ller and Anna {\AA}berg and Jurate Straseviçiene and Levente Emődy and Bernt Eric Uhlin and Carlos Balsalobre},
  journal={PLoS Pathogens},
  year={2009},
  volume={5},
  pages={57 - 60}
}
Type 1 fimbriae are a crucial factor for the virulence of uropathogenic Escherichia coli during the first steps of infection by mediating adhesion to epithelial cells. They are also required for the consequent colonization of the tissues and for invasion of the uroepithelium. Here, we studied the role of the specialized signal transduction system CRP-cAMP in the regulation of type 1 fimbriation. Although initially discovered by regulating carbohydrate metabolism, the CRP-cAMP complex controls a… CONTINUE READING
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