Type III Polyketide Synthases: Functional Classification and Phylogenomics.

  title={Type III Polyketide Synthases: Functional Classification and Phylogenomics.},
  author={Yugo Shimizu and Hiroyuki Ogata and Susumu Goto},
  journal={Chembiochem : a European journal of chemical biology},
  volume={18 1},
Polyketide synthases (PKSs) catalyze the sequential condensation of simple acetate units to produce a large class of natural products, including pharmacologically valuable compounds. PKSs are classified into three types on the basis of their domain structures; type III PKSs have the simplest domain structure, although their products have various structures and functions. The sequence-function relationship is fundamental for predicting enzyme functions, but it has not been well investigated in… CONTINUE READING
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