Type II toxin: antitoxin systems. More than small selfish entities?

@article{Rocker2015TypeIT,
  title={Type II toxin: antitoxin systems. More than small selfish entities?},
  author={Andrea Rocker and Anton Meinhart},
  journal={Current Genetics},
  year={2015},
  volume={62},
  pages={287-290}
}
Toxin–antitoxin (TA) modules regulate metabolism and viability of bacteria and archaea. In type II TA systems these functions are generally thought to be performed by two small proteins. However, evidence is increasing that the toxins are much more diverse and can form multi-domain proteins. Recently, we published a novel type II TA system in which toxin and antitoxin are covalently linked into a single polypeptide chain. In this review we summarize the current knowledge on these elongated… CONTINUE READING
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Garcia-Pino A (2014) Disorder- and dynamics-based regulatory mechanisms in toxin–antitoxin modules

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