Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

  title={Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome},
  author={J{\'e}r{\^o}me Galon and Anne Costes and F{\'a}tima S{\'a}nchez-Cabo and Amos Kirilovsky and Bernhard Mlecnik and Christine Lagorce-Pagès and Marie Tosolini and Matthieu Camus and Anne Berger and Ph. Wind and Franck Zinzindohoué and Patrick Bruneval and Paul-Henri Cugnenc and Zlatko Trajanoski and Wolf Herman Fridman and Franck Pag{\`e}s},
  pages={1960 - 1964}
The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data (the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods… 

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An Immune Atlas of Clear Cell Renal Cell Carcinoma

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Effector memory T cells, early metastasis, and survival in colorectal cancer.

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Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.

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Prognostic value of the CD4+/CD8+ ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells

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The identification of human tumor rejection antigens opens new possibilities for systematic approaches to the specific immune therapy of cancer.

The three Es of cancer immunoediting.

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