TypA is involved in virulence, antimicrobial resistance and biofilm formation in Pseudomonas aeruginosa

@inproceedings{Neidig2012TypAII,
  title={TypA is involved in virulence, antimicrobial resistance and biofilm formation in Pseudomonas aeruginosa},
  author={Anke Neidig and Amy T. Y. Yeung and Thibaut Rosay and Beatrix Tettmann and Nikola Strempel and Martina Rueger and Olivier Lesouhaitier and Joerg Overhage},
  booktitle={BMC Microbiology},
  year={2012}
}
Pseudomonas aeruginosa is an important opportunistic human pathogen and is extremely difficult to treat due to its high intrinsic and adaptive antibiotic resistance, ability to form biofilms in chronic infections and broad arsenal of virulence factors, which are finely regulated. TypA is a GTPase that has recently been identified to modulate virulence in enteric Gram-negative pathogens. Here, we demonstrate that mutation of typA in P. aeruginosa resulted in reduced virulence in phagocytic… CONTINUE READING
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REW: The Lon protease is essential for full virulence in Pseudomonas aeruginosa

  • L Breidenstein EBM, J Janot, +7 authors Hancock
  • 2012
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