Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells.

@article{Nakamura2008Tyk2signalingPA,
  title={Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells.},
  author={Risa Nakamura and Kensuke Shibata and Hisakata Yamada and Kazuya Shimoda and Keiichi Nakayama and Yasunobu Yoshikai},
  journal={Journal of immunology},
  year={2008},
  volume={181 3},
  pages={2071-5}
}
Tyrosine kinase 2 (Tyk2), a member of the JAK-signal transducer family, is involved in intracellular signaling triggered by various cytokines, including IL-23. We have recently reported that resident gammadelta T cells in the peritoneal cavity of naive mice produced IL-17 in response to IL-23. In this study, we examined importance of Tyk2-mediated signaling in the IL-17 production by gammadelta T cells using Tyk2 deficient (-/-) mice. Gammadelta T cells in the peritoneal cavity of Tyk2… CONTINUE READING

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