Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.

@article{Shimoda2000Tyk2PA,
  title={Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.},
  author={Kazuya Shimoda and Kosuke Kato and Kenta Aoki and Tadashi Matsuda and Alison Miyamoto and Masafumi Shibamori and Masakatsu Yamashita and Akihiko Numata and Kan Takase and Susumu Kobayashi and Shun-ichi Shibata and Yumi Asano and Hisashi Gondo and Kiyotoshi Sekiguchi and Toshinori Nakayama and Takayuki Okamura and Seiichi Okamura and Yoshiyuki Niho and Koichi Nakayama},
  journal={Immunity},
  year={2000},
  volume={13 4},
  pages={561-71}
}
Janus kinases (Jaks) play an important role in signal transduction via cytokine receptors. Tyk2 is a Janus kinase, and we developed tyk2-deficient mice to study the requirement for tyk2 in vivo. Tyk2-deficient mice show no overt developmental abnormalities; however, they display a lack of responsiveness to a small amount of IFNalpha, although a high concentration of IFNalpha can fully transduce its signal even in the absence of tyk2. Furthermore, IL-12-induced T cell function is defective in… CONTINUE READING