Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.

Abstract

Mice lacking the Jak tyrosine kinase member Tyk2 become progressively obese due to aberrant development of Myf5+ brown adipose tissue (BAT). Tyk2 RNA levels in BAT and skeletal muscle, which shares a common progenitor with BAT, are dramatically decreased in mice placed on a high-fat diet and in obese humans. Expression of Tyk2 or the constitutively active… (More)
DOI: 10.1016/j.cmet.2012.11.005

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@article{Derecka2012Tyk2AS, title={Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.}, author={Marta Derecka and Agnieszka Gornicka and Sergei B. Koralov and Karol Szczepanek and Magdalena K. Morgan and Vidisha Raje and Jennifer Sisler and Qifang Zhang and Dennis C. Otero and Joanna Cichy and K. Rajewsky and Kazuya Shimoda and Valeria Poli and Birgit Strobl and Sandra Pellegrini and Thurl E. Harris and Patrick Seale and Aaron Russell and Andrew J. McAinch and Paul O'Brien and Susanna Renata Keller and Colleen M Croniger and Tomasz Kordula and Andrew C Larner}, journal={Cell metabolism}, year={2012}, volume={16 6}, pages={814-24} }