Tying up loose ends: ribosome recycling in eukaryotes and archaea.

  title={Tying up loose ends: ribosome recycling in eukaryotes and archaea.},
  author={Elina N{\"u}renberg and Robert Tamp{\'e}},
  journal={Trends in biochemical sciences},
  volume={38 2},
Ribosome recycling is the final - or first - step of the cyclic process of mRNA translation. In eukaryotes and archaea, dissociation of the two ribosomal subunits proceeds in a fundamentally different way than in bacteria. It requires the ABC-type ATPase ABCE1 [previously named RNase L inhibitor (Rli)1 or host protein (HP)68], but the reaction and its regulation remain enigmatic. Here, we focus on ribosome recycling in its physiological context, including translation termination and… CONTINUE READING
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