Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry.

@article{Nowak2014Ty3RT,
  title={Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry.},
  author={E. Popowska - Nowak and Jennifer T. Miller and Marion K Bona and Justyna Studnicka and Roman H. Szczepanowski and Jakub Jurkowski and Stuart F. J. Le Grice and Marcin Nowotny},
  journal={Nature structural & molecular biology},
  year={2014},
  volume={21 4},
  pages={389-96}
}
Retrotransposons are a class of mobile genetic elements that replicate by converting their single-stranded RNA intermediate to double-stranded DNA through the combined DNA polymerase and ribonuclease H (RNase H) activities of the element-encoded reverse transcriptase (RT). Although a wealth of structural information is available for lentiviral and gammaretroviral RTs, equivalent studies on counterpart enzymes of long terminal repeat (LTR)-containing retrotransposons, from which they are… CONTINUE READING
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