Two zinc fingers of a yeast regulatory protein shown by genetic evidence to be essential for its function

Abstract

The best-understood protein structure involved in DNA binding is the helix-turn-helix motif1. A second DNA-binding domain, the finger structure, has been proposed on the basis of sequence analysis2,3, partial proteolysis2 and zinc content2 of Xenopus transcription factor TFIIIA. Other eukaryotic proteins were subsequently found to contain contiguous repeat… (More)
DOI: 10.1038/328443a0

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