Two-year clinical and immune outcomes in human immunodeficiency virus-infected children who reconstitute CD4 T cells without control of viral replication after combination antiretroviral therapy.

@article{Ghaffari2004TwoyearCA,
  title={Two-year clinical and immune outcomes in human immunodeficiency virus-infected children who reconstitute CD4 T cells without control of viral replication after combination antiretroviral therapy.},
  author={Guity Ghaffari and Dominick J. Passalacqua and Jennifer L. Caicedo and Maureen Michels Goodenow and John William Sleasman},
  journal={Pediatrics},
  year={2004},
  volume={114 5},
  pages={
          e604-11
        }
}
OBJECTIVE To evaluate 96-week clinical and immune outcomes to protease inhibitor-containing antiretroviral therapy. METHODS A prospective study was conducted of 40 human immunodeficiency virus (HIV)-infected children who displayed viral suppression (VS) with successful immune reconstitution (IS), failure to suppress virus (VF) or develop immune reconstitution (IF), or discordant immune and viral responses (VF/IS) at 24 weeks posttherapy. All children enrolled had viral RNA >4.0 log10 copies… CONTINUE READING
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