Two-year carcinogenicity study of 6-mercaptopurine in F344 rats

@article{Maekawa2005TwoyearCS,
  title={Two-year carcinogenicity study of 6-mercaptopurine in F344 rats},
  author={Akihiko Maekawa and Takaharu Nagaoka and Hiroshi Onodera and Yuko Matsushima and Asahi Todate and Makoto Shibutani and Hiroyuki Ogasawara and Yukio Kodama and Yuzo Hayashi},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2005},
  volume={116},
  pages={245-250}
}
SummaryThe carcinogenicity of 6-mercaptopurine (6-MP), an anticancer drug, was examined in F344 rats of both sexes, administered the chemical at dietary levels of 0 (control), 25 ppm or 50 ppm for 2 years. Many tumors developed in all groups including the control group, the organ distribution and histological types being similar to those reported for spontaneous lesions. In males, there was no significant increase in the incidence of any tumor in the treated groups over that in the control… 
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