Two-year carcinogenicity study of 6-mercaptopurine in F344 rats

  title={Two-year carcinogenicity study of 6-mercaptopurine in F344 rats},
  author={Akihiko Maekawa and Takaharu Nagaoka and Hiroshi Onodera and Yuko Matsushima and Asahi Todate and Makoto Shibutani and Hiroyuki Ogasawara and Yukio Kodama and Yuzo Hayashi},
  journal={Journal of Cancer Research and Clinical Oncology},
SummaryThe carcinogenicity of 6-mercaptopurine (6-MP), an anticancer drug, was examined in F344 rats of both sexes, administered the chemical at dietary levels of 0 (control), 25 ppm or 50 ppm for 2 years. Many tumors developed in all groups including the control group, the organ distribution and histological types being similar to those reported for spontaneous lesions. In males, there was no significant increase in the incidence of any tumor in the treated groups over that in the control… 
2 Citations
Understanding the proliferative and self-renewal potential of different leukaemic stem cell populations
This book presents a systematic treatment of the natural history of Yellowstone National Park in the period of June 21 to 29, 1997 with a focus on the activities of the June-to-September period.


The brain-tumour issue in long-term toxicity studies in rats.
  • A. Koestner
  • Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1986
Dominant-lethal test of 6-mercaptopurine: dependence on dosage, duration and route of administration.
A dominant-lethal test of 6-mercaptopurine was carried out in male mice with four intraperitoneal, two oral, and one subcutaneous dosage levels, and a genetic risk was proved at the periods of meiotic division and late premeiotic stages of spermatogenesis, manifested by increased percentages of fetal resorptions.
Natural history of body weight gain, survival, and neoplasia in the F344 rat.
The data indicated that life-span studies in F344 rats had no advantages over 2-year studies, and Variety of neoplastic lesions in animals that were allowed to live out their life- span was not greater than that in animals That were killed between 110 and 116 weeks of age; thus older age was not characterized by unique neoplasms.
Neoplastic and nonneoplastic lesions in aging F344 rats.
Use of Historical Control Data in Carcinogenicity Studies in Rodents
Tumor incidence data from untreated Fischer 344 rats and B6C3F1 mice in the National Toxicology Program (NTP) historical control database is summarized.
Mammalian in vivo and in vitro cytogenetic assays: a report of the U.S. EPA's gene-tox program.