Two-year carcinogenicity study of 6-mercaptopurine in F344 rats

@article{Maekawa2005TwoyearCS,
  title={Two-year carcinogenicity study of 6-mercaptopurine in F344 rats},
  author={Akihiko Maekawa and Takaharu Nagaoka and Hiroyoshi Onodera and Yuko Matsushima and Asahi Todate and Makoto Shibutani and Hiroyuki Ogasawara and Yukio Kodama and Yuzo Hayashi},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2005},
  volume={116},
  pages={245-250}
}
  • Akihiko Maekawa, Takaharu Nagaoka, +6 authors Yuzo Hayashi
  • Published 2005
  • Medicine
  • Journal of Cancer Research and Clinical Oncology
  • SummaryThe carcinogenicity of 6-mercaptopurine (6-MP), an anticancer drug, was examined in F344 rats of both sexes, administered the chemical at dietary levels of 0 (control), 25 ppm or 50 ppm for 2 years. Many tumors developed in all groups including the control group, the organ distribution and histological types being similar to those reported for spontaneous lesions. In males, there was no significant increase in the incidence of any tumor in the treated groups over that in the control… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 13 REFERENCES

    The brain-tumour issue in long-term toxicity studies in rats.

    • Adalbert Koestner
    • Biology, Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 1986

    Brain tumours--problems and perspectives.

    • James A. Swenberg
    • Biology, Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 1986
    VIEW 1 EXCERPT