Two weeks of muscle immobilization impairs functional sympatholysis but increases exercise hyperemia and the vasodilatory responsiveness to infused ATP.

@article{Mortensen2012TwoWO,
  title={Two weeks of muscle immobilization impairs functional sympatholysis but increases exercise hyperemia and the vasodilatory responsiveness to infused ATP.},
  author={Stefan P Mortensen and Jacob M\orkeberg and Pia Thaning and Ylva Hellsten and Bengt Saltin},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2012},
  volume={302 10},
  pages={H2074-82}
}
During exercise, contracting muscles can override sympathetic vasoconstrictor activity (functional sympatholysis). ATP and adenosine have been proposed to play a role in skeletal muscle blood flow regulation. However, little is known about the role of muscle training status on functional sympatholysis and ATP- and adenosine-induced vasodilation. Eight male subjects (22 ± 2 yr, Vo(2max): 49 ± 2 ml O(2)·min(-1)·kg(-1)) were studied before and after 5 wk of one-legged knee-extensor training (3-4… CONTINUE READING
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