Two-week inhalation toxicity of polymeric diphenylmethane-4, 4'-diisocyanate (PMDI) in rats: analysis of biochemical and morphological markers of early pulmonary response.

@article{Pauluhn1999TwoweekIT,
  title={Two-week inhalation toxicity of polymeric diphenylmethane-4, 4'-diisocyanate (PMDI) in rats: analysis of biochemical and morphological markers of early pulmonary response.},
  author={Juergen Pauluhn and Makito Emura and Ulrich Mohr and Andreas Popp and Martin Rosenbruch},
  journal={Inhalation toxicology},
  year={1999},
  volume={11 12},
  pages={1143-63}
}
The pulmonary response of Wistar rats to respirable polymeric diphenylmethane-4,4'-diisocyanate (PMDI) aerosol was examined in a 2-wk repeated nose-only inhalation exposure study. Exposure concentrations were 1.1, 3.3, and 13.7 mg PMDI/m(3) (6 h/day, 15 exposures). The level of 13.7 mg/m(3) was actually a combination of an initial target concentration of 10… CONTINUE READING