Two-way nanopore sensing of sequence-specific oligonucleotides and small-molecule targets in complex matrices using integrated DNA supersandwich structures.

@article{Liu2013TwowayNS,
  title={Two-way nanopore sensing of sequence-specific oligonucleotides and small-molecule targets in complex matrices using integrated DNA supersandwich structures.},
  author={Nannan Liu and Yanan Jiang and Yahong Zhou and Fan Xia and Wei Guo and Lei Jiang},
  journal={Angewandte Chemie},
  year={2013},
  volume={52 7},
  pages={2007-11}
}
Recent advances in molecular science and nanotechnology offer unprecedented opportunities to miniaturize chemical analysis systems into nanofluidic devices that mimic ion channels and have single-molecule sensitivity, target-specific selectivity, and reduced consumption of materials. When analytes are present in the nanofluidic sensing system, they temporarily or permanently block the pathway for ion conduction, yielding characteristic changes in background current that serves as a signature… CONTINUE READING