Two-wave nanotherapy to target the stroma and optimize gemcitabine delivery to a human pancreatic cancer model in mice.

@article{Meng2013TwowaveNT,
  title={Two-wave nanotherapy to target the stroma and optimize gemcitabine delivery to a human pancreatic cancer model in mice.},
  author={Huan Meng and Yang Zhao and Juyao Ivy Dong and Minje Xue and Yu-shen Lin and Zhaoxia Ji and Wilson X. Mai and Haiyuan Zhang and Chong Hyun Chang and C. Jeffrey Brinker and Jeffrey I. Zink and Andr{\'e} E Nel},
  journal={ACS nano},
  year={2013},
  volume={7 11},
  pages={
          10048-65
        }
}
Pancreatic ductal adenocarcinoma (PDAC) elicits a dense stromal response that blocks vascular access because of pericyte coverage of vascular fenestrations. In this way, the PDAC stroma contributes to chemotherapy resistance in addition to causing other problems. In order to improve the delivery of gemcitabine, a first-line chemotherapeutic agent, a PEGylated drug-carrying liposome was developed, using a transmembrane ammonium sulfate gradient to encapsulate the protonated drug up to 20% w/w… Expand
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