Two types of sporadic cerebral amyloid angiopathy.

  title={Two types of sporadic cerebral amyloid angiopathy.},
  author={Dietmar Rudolf Thal and Estifanos Ghebremedhin and Udo R{\"u}b and Haruyasu Yamaguchi and Kelly del Tredici and Heiko Braak},
  journal={Journal of neuropathology and experimental neurology},
  volume={61 3},
Cerebral amyloid angiopathy (CAA) is a type of beta-amyloidosis that occurs in leptomeningeal and cortical vessels of the elderly. In a sample of 41 CAA cases including 16 Alzheimer disease (AD) cases and 28 controls, we show that 2 types of sporadic CAA exist: The first type is characterized by immunohistochemically detectable amyloid beta-protein (Abeta) in cortical capillaries, leptomeningeal and cortical arteries, arterioles, veins, and venules. It is referred to here as CAA-Type 1. The… CONTINUE READING
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