Two types of receptor for insulin-like growth factors in mammalian brain.

@article{Gammeltoft1985TwoTO,
  title={Two types of receptor for insulin-like growth factors in mammalian brain.},
  author={Steen Gammeltoft and Gisela K. Haselbacher and Ren{\'e} E. Humbel and M. Fehlmann and E Van Obberghen},
  journal={The EMBO journal},
  year={1985},
  volume={4 13A},
  pages={
          3407-12
        }
}
Two types of receptor for insulin-like growth factors (IGFs) have been identified on adult rat and human brain plasma membranes by competitive binding assay, affinity labelling, receptor phosphorylation and interaction with antibodies to insulin receptors. The type I IGF receptor consists of two species of subunits: alpha-subunits (mol. wt. approximately 115 000), which bind IGF I and IGF II with almost equal affinity and beta-subunits (mol. wt. approximately 94 000), the phosphorylation of… CONTINUE READING
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