Two types of hippocampal rhythmical slow activity in both the rabbit and the rat: Relations to behavior and effects of atropine, diethyl ether, urethane, and pentobarbital

@article{Kramis1975TwoTO,
  title={Two types of hippocampal rhythmical slow activity in both the rabbit and the rat: Relations to behavior and effects of atropine, diethyl ether, urethane, and pentobarbital},
  author={Ronald C. Kramis and Case H. Vanderwolf and Brian H. Bland},
  journal={Experimental Neurology},
  year={1975},
  volume={49},
  pages={58-85}
}
Abstract A series of experiments in rats and rabbits indicates that the hip;ocampus receives two nonspecific inputs from the brain stem, each capable of producing rhythmical slow activity (theta rhythm). One type of theta rhythm can be abolished by injections of atropine sulfate (5 mg/kg, iv, or 25–50 mg/kg, ip) but not by atropine methyl nitrate. Such theta activity typically has a frequency of 4 7 Hz and occurs during ether or urethane anesthesia as well as during behavioral immobility in the… Expand
Spontaneous EEG spikes in the normal hippocampus. V. Effects of ether, urethane, pentobarbital, atropine, diazepam and bicuculline.
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Results suggest that the SPK generation mechanism in the hippocampus is sensitive to the level of GABA-mediated inhibition, and the effects of various systemically administered drugs on hippocampal SPK activity are examined. Expand
The effect of atropine administered in the medial septum or hippocampus on high‐ and low‐frequency theta rhythms in the hippocampus of urethane anesthetized rats
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It is concluded that the theta suppressing effect of atropine involves both hippocampal and septal mechanisms and that low‐frequency theta as compared with fast theta rhythm is more sensitive to muscarinic acetylcholine receptor antagonism in the MS but not in the hippocampus. Expand
Hippocampal EEG responses induced by carbachol and atropine infusions into the septum and the hippocampus in the urethane-anaesthetized rat
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The data demonstrate that muscarinic receptors in the septum are predominant sites for cholinergic agonist-antagonist action capable of generating or suppressing hippocampal theta in the rat and indicate that intraseptal cholinerg mechanisms play an important role in the initiation and generation of this rhythm. Expand
Electrical activity of the hippocampus and neocortex in rats depleted of brain dopamine and norepinephrine: Relations to behavior and effects of atropine
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EEG recordings revealed that both atropine-resistant (movement-related) forms of neocortical low-voltage, fast activity (LVFA) and hippocampal rhythmic slow activity (RSA or theta) survive depletion of brain DA and NE. Expand
Detection of an atropine-resistant component of the hippocampal theta rhythm in urethane-anesthetized rats
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The coupling of the signal to the atropine-resistant septal cells strengthens the previous suggestion that these septo-hippocampal neurons are not cholinergic, and are therefore probably GABAergic. Expand
Hippocampal rhythmical slow activity following ibotenic acid lesions of the septal region. I. Relations to behavior and effects of atropine and urethane
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The results suggest that intrinsic septal circuitry is critically involved in the generation of the atropine-sensitive (presumably cholinergic) form of RSA and the mechanisms by which LIA and the two forms of RSA are generated in the hippocampus. Expand
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TLDR
The effect of atropine on AEPs may be interpreted as a direct effect on the hippocampus which is apparently inconsistent with present knowledge, and the hypothesis that there are two pharmacological types of RSA (atropine-sensitive and -resistant) requires re-definition and re-examination. Expand
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TLDR
Sodium amylobarbitone appears to affect control of hippocampal theta rhythm by actions on two systems, only one of which is dependent on noradrenaline. Expand
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  • Chemistry, Medicine
  • Electroencephalography and clinical neurophysiology
  • 1985
TLDR
The main effects of drugs and behavior on the residue spectra and on the average evoked potentials following stimulation of the Schaffer collaterals could be explained by a previously proposed model (Leung 1982) which suggests a continuum of hippocampal 'activation' (tonic input) under the various conditions. Expand
Generation of Theta and Gamma Rhythms in the Hippocampus
  • L. S. Leung
  • Psychology, Medicine
  • Neuroscience & Biobehavioral Reviews
  • 1998
TLDR
In the behaving rat, theta rhythm was dominant during walking and rapid-eye-movement sleep, while irregular slow activity predominated during immobility and slow-wave sleep, and single cell recordings in vitro suggested that intrinsic voltage-dependent membrane potential oscillations modulate the response to a theta-frequency driving. Expand
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Evidence is presented to suggest that the hippocampus receives 2 nonspecific inputs from the brainstem, each capable of producing rhythmical slow activity. The neocortex appears to receive 2 similarExpand
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Experimental studies attempting to relate brain electrical activity to behavior have become commonplace in the last 25 years. During this period, there have been many advances in the development ofExpand
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