Two types of calcium channels in guinea pig ventricular myocytes.

  title={Two types of calcium channels in guinea pig ventricular myocytes.},
  author={Raman Mitra and Martin Morad},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={83 14},
In cardiac muscle, Ca2+ plays a key role in regulation of numerous processes, including generation of the action potential and development of tension. The entry of Ca2+ into the cell is regulated primarily by voltage-gated channels in the membrane. Until recently, it was felt that only one type of Ca2+ channel existed in cardiac ventricular muscle. Experiments reported here suggest that in isolated guinea pig ventricular myocytes, there are two distinct types of Ca2+ channels with markedly… CONTINUE READING


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