Two types of anti-progestins have distinct effects on site-specific phosphorylation of human progesterone receptor.

@article{Beck1996TwoTO,
  title={Two types of anti-progestins have distinct effects on site-specific phosphorylation of human progesterone receptor.},
  author={Candace A. Beck and Yi Zhang and Nancy L. Weigel and Dean P. Edwards},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 2},
  pages={1209-17}
}
Human progesterone receptor (PR) is phosphorylated on multiple serine residues; three sites (Ser102, Ser294, and Ser345) are inducible by hormone agonist, while at least six others are basally phosphorylated and exhibit a general increase in response to hormone. In this study we have used high performance liquid chromatography phosphopeptide mapping and manual peptide sequencing to investigate how two different progestin antagonists, RU486 and ZK98299, affect site-specific phosphorylation of PR… CONTINUE READING