Two types of acid-sensing ion channel currents in rat hippocampal neurons

@article{Weng2004TwoTO,
  title={Two types of acid-sensing ion channel currents in rat hippocampal neurons},
  author={Xie-chuan Weng and Jian-quan Zheng and Xiao-dan Gai and Jin Li and Wen-bin Xiao},
  journal={Neuroscience Research},
  year={2004},
  volume={50},
  pages={493-499}
}
Two types of acid-sensing ion channel (ASIC)-like currents in cultured rat hippocampal neurons were recorded and their characteristics were studied by using a whole-cell recording technique. The results revealed that the ASIC-like currents, induced by a quick drop of the extracellular pH, decayed with different time constants (tau) of 229 +/- 16 (Type I) and 1209 +/- 56 ms (Type II). The ASIC-like currents displayed different sensitivities to extracellular proton (pH0.5 was 6.17 +/- 0.04 for… CONTINUE READING

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