Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia.

@article{Zebisch2006TwoTC,
  title={Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia.},
  author={Armin Zebisch and Philipp B Staber and A. Fallah Delavar and Claudia Bodner and Karin Hiden and Katja Fischereder and M. Janakiraman and Werner Linkesch and Holger W Auner and W. Emberger and Christian Windpassinger and Michael G. Schimek and Gerald Hoefler and J Troppmair and Heinz Sill},
  journal={Cancer research},
  year={2006},
  volume={66 7},
  pages={3401-8}
}
Mutations leading to activation of the RAF-mitogen-activated protein kinase/extracellular signal-regulated (ERK) kinase (MEK)-ERK pathway are key events in the pathogenesis of human malignancies. In a screen of 82 acute myeloid leukemia (AML) samples, 45 (55%) showed activated ERK and thus were further analyzed for mutations in B-RAF and C-RAF. Two C-RAF germ-line mutations, S427G and I448V, were identified in patients with therapy-related AML in the absence of alterations in RAS and FLT3. Both… CONTINUE READING

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