Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.

@article{Ng2011TwoTF,
  title={Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.},
  author={Lily C. Y. Ng and Ailing Lu and Alok Swaroop and David S. Sharlin and Anand Swaroop and Douglas Forrest},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 31},
  pages={11118-25}
}
The typical mammalian visual system is based upon three photoreceptor types: rods for dim light vision and two types of cones (M and S) for color vision in daylight. However, the process that generates photoreceptor diversity and the cell type in which diversity arises remain unclear. Mice deleted for thyroid hormone receptor β2 (TRβ2) and neural retina leucine zipper factor (NRL) lack M cones and rods, respectively, but gain S cones. We therefore tested the hypothesis that NRL and TRβ2 direct… CONTINUE READING
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