Two- to 9-Year Outcome After Autologous Chondrocyte Transplantation of the Knee

@article{Peterson2000TwoT9,
  title={Two- to 9-Year Outcome After Autologous Chondrocyte Transplantation of the Knee},
  author={Lars Peterson and Tom Minas and Mats Brittberg and Anders Nilsson and Eva Sj{\"o}gren-Jansson and Anders Lindahl},
  journal={Clinical Orthopaedics and Related Research},
  year={2000},
  volume={\&NA;},
  pages={212-234}
}
Autologous cultured chondrocyte transplantation was introduced in Sweden in 1987 for the treatment of large (1.5-12.0 cm2) full thickness chondral defects of the knee. The clinical, arthroscopic, and histologic results from the first 101 patients treated using this technique are reported in this study. Patients were assessed retrospectively using three types of endpoints: patient and physician derived clinical rating scales (five validated and two new); arthroscopic assessment of cartilage fill… Expand
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TLDR
Autologous chondrocyte implantation provides an appropriate method for the treatment of full-thickness cartilage lesions of the knee and gives good clinical short-term results. Expand
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10 Autologous Chondrocyte Implantation
Currently, autologous chondrocyte implantation (ACI) is ideally indicated for symptomatic ICRS grade III–IV lesions greater than 2 cm2 along the femoral condyle or trochlear regions. High-demand… Expand
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  • T. Minas
  • Medicine
  • Clinical orthopaedics and related research
  • 2001
TLDR
Autologous chondrocyte implantation has been used since March 1995 in a prospective cohort evaluation and there were 22 failures in 169 patients treated, which was defined as no clinical improvement or graft failure. Expand
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MACI provides a stable midterm chondral replacement strategy for osteochondral lesions that fail initial microfracture in patients with OLTs who had failed previous arthroscopic treatment. Expand
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Evidence of the medium-term benefit achieved by transplanting autologous chondrocytes to osteochondral defects is provided, maintained for up to six years, in knee symptoms compared to pre-operative levels. Expand
Autologous chondrocyte implantation.
TLDR
This chapter will describe the technique of ACI, as well as additional methods to deal with the various complex problems that can arise during these demanding procedures, and review and discuss developing literature supporting current use of various matrices in combination with autologous chondrocytes. Expand
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It is demonstrated that MACT, regardless of the implants used, resulted in good clinical improvement two years after transplantation for localized tibiofemoral defects. Expand
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It is believed that ACI is appropriate in the management of carefully selected adolescents with symptomatic chondral and osteochondral defects and significant improvement in postoperative function after ACI or MACI. Expand
Autologous Chondrocyte Transplantation for the Treatment of Articular Defects of the Knee
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The autologous chondrocyte transplantation combined with tissue glue Tissucol (Baxter, Austria) provides stable short-term outcomes with high percentage of good to excellent results – 71 % of patients (according to the Lysholm knee score). Expand
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