Two suspected cases of immunoglobulin-mediated interference causing falsely low vancomycin concentrations with the Beckman PETINIA method.

@article{Gunther2013TwoSC,
  title={Two suspected cases of immunoglobulin-mediated interference causing falsely low vancomycin concentrations with the Beckman PETINIA method.},
  author={Mary Gunther and Lynora Saxinger and Margaret E. Gray and Donald F Legatt},
  journal={The Annals of pharmacotherapy},
  year={2013},
  volume={47 4},
  pages={e19}
}
OBJECTIVE To describe 2 recent cases of suspected immunoglobulin-mediated interference with the Beckman Coulter particle-enhanced turbidimetric inhibition immunoassay (PETINIA) used to measure vancomycin serum or plasma concentrations and to review the existing literature. CASE SUMMARY A 64-year-old woman with a history of multiple immune-related comorbidities received vancomycin for treatment of a prosthetic joint infection growing coagulase-negative Staphylococcus spp. A 33-year-old man… CONTINUE READING
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