Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

@article{Sallusto1999TwoSO,
  title={Two subsets of memory T lymphocytes with distinct homing potentials and effector functions},
  author={Federica Sallusto and Danielle Lenig and Reinhold F{\"o}rster and Martin Lipp and Antonio Lanzavecchia},
  journal={Nature},
  year={1999},
  volume={401},
  pages={708-712}
}
Naive T lymphocytes travel to T-cell areas of secondary lymphoid organs in search of antigen presented by dendritic cells. Once activated, they proliferate vigorously, generating effector cells that can migrate to B-cell areas or to inflamed tissues. A fraction of primed T lymphocytes persists as circulating memory cells that can confer protection and give, upon secondary challenge, a qualitatively different and quantitatively enhanced response. The nature of the cells that mediate the… 
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