Two steroid 21-hydroxylase genes are located in the murine S region

  title={Two steroid 21-hydroxylase genes are located in the murine S region},
  author={Perrin C White and David D. Chaplin and John H. Weis and Bryony Dupont and Maria I. New and Jonathan G Seidman},
A common inherited disorder of steroidogenesis in man, 21-hydroxylase (21-OH) deficiency, is linked to the HLA major histocompatibility complex (MHC)1, and is associated in particular with certain allotypes of the HLA-linked complement proteins2,3. Recently, this disorder was demonstrated to result from a defective structural gene for the 21-OH enzyme, also termed cytochrome P-450C21 (ref. 4). The human (HLA) and murine (H–2) MHCs are homologous in overall organization and in the structures of… CONTINUE READING


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