Two steps in the assembly of complexes at yeast replication origins in vivo.

@article{Diffley1994TwoSI,
  title={Two steps in the assembly of complexes at yeast replication origins in vivo.},
  author={John F X Diffley and Julie H. Cocker and Simon J. Dowell and Adele Rowley},
  journal={Cell},
  year={1994},
  volume={78 2},
  pages={303-16}
}
The integration of chromosomal DNA replication into the eukaryotic cell cycle might involve temporal regulation of interactions between cellular factors and replication origins. We show here that yeast replication origins exist in two chromatin states during the cell cycle. In the postreplicative state, genomic footprints closely resemble those produced in vitro by the purified ORC and ABF1 proteins, indicating that the binding of these proteins to replication origins is not sufficient to drive… CONTINUE READING
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