Two-step chromatography purification of IgGs possessing sialidase activity from human blood serum.

@article{Kit2015TwostepCP,
  title={Two-step chromatography purification of IgGs possessing sialidase activity from human blood serum.},
  author={Y. Kit and R. Bilyy and Nataliya Korniy and A. Tomin and V. Chopyak and Y. Tolstyak and V. Antonyuk and R. Stoika},
  journal={Biomedical chromatography : BMC},
  year={2015},
  volume={29 3},
  pages={
          328-32
        }
}
  • Y. Kit, R. Bilyy, +5 authors R. Stoika
  • Published 2015
  • Chemistry, Medicine
  • Biomedical chromatography : BMC
  • Sialation of cell surface is known to be tightly connected with tumorigenicity, invasiveness, metastatic potential and clearance of aged cells, while sialation of immunoglobulin G (IgG) molecules determines their anti-inflammatory properties. Recently, we have found for the first time IgG-antibodies possessing sialidase-like activity (sialylic abzyme) in blood serum of multiple myeloma and systemic lupus erythematosis patients. This abzyme was detected in a pool of IgGs purified by a typical… CONTINUE READING
    1 Citations

    References

    SHOWING 1-10 OF 28 REFERENCES
    Antibody‐mediated sialidase activity in blood serum of patients with multiple myeloma
    • 11
    Catalytic Activity of Anti‐Thyroglobulin Antibodies a
    • 150
    Metal dependent hydrolysis of β‐casein by sIgA antibodies from human milk
    • 21
    Phosphorylation of different human milk proteins by human catalytic secretory immunoglobulin A
    • 46