Two-stage strategies to detect gene × gene interactions in case-control data

@article{Barhdadi2007TwostageST,
  title={Two-stage strategies to detect gene × gene interactions in case-control data},
  author={Amina Barhdadi and Marie-Pierre Dub{\'e}},
  journal={BMC Proceedings},
  year={2007},
  volume={1},
  pages={S135 - S135}
}
Large genetic association studies based on hundreds of thousands of single-nucleotide polymorphisms (SNPs) are a popular option for the study of complex diseases. The evaluation of gene x gene interactions in such studies is a sensible method of capturing important genetic effects. The number of tests required to consider all pairs of SNPs, however, can lead to a computational burden, and efficient strategies to reduce the number of tests performed are desirable. In this study, we compare two… CONTINUE READING