Two-stage model of memory trace formation: A role for “noisy” brain states

@article{Buzski1989TwostageMO,
  title={Two-stage model of memory trace formation: A role for “noisy” brain states},
  author={Gy{\"o}rgy Buzs{\'a}ki},
  journal={Neuroscience},
  year={1989},
  volume={31},
  pages={551-570}
}
  • G. Buzsáki
  • Published 31 December 1989
  • Biology
  • Neuroscience
Oscillatory and Intermittent Synchrony in the Hippocampus: Relevance to Memory Trace Formation
TLDR
This field potential reflects summated EPSPs in the apical dendrites of CA1 pyramidal neurons as a result of population synchrony in the CA3 recurrent network.
Reactivation of behavioral activity during sharp waves: A computational model for two stage hippocampal dynamics
TLDR
It is demonstrated here that patterns of reactivation can be successfully reproduced by relying on a computational model of the hippocampus with theta phase precession and synaptic plasticity during theta rhythm to initiate SPWs events.
Temporal redistribution of inhibition over neuronal subcellular domains underlies state-dependent rhythmic change of excitability in the hippocampus
TLDR
The behaviour-contingent rhythmic synchronization of neuronal activity is reported by local field potential oscillations in the theta, gamma and sharp wave-related ripple (SWR) frequency ranges and the key inhibitory role of axo-axonic cells is demonstrated.
Memory consolidation during sleep: a neurophysiological perspective
TLDR
It is suggested that sleep patterns in the limbic system are essential for the preservation of experience‐induced synaptic modifications and the subcortical effects of hippocampal sharp wave bursts may be critical in the release of various hormones which, in turn, may affect synaptic plasticity.
Cell Type-Specific Synaptic Dynamics of Synchronized Bursting in the Juvenile CA3 Rat Hippocampus
TLDR
It is shown that the first manifestation of a burst event is a cell type-specific flurry of GABAA receptor-mediated inhibitory input to pyramidal cells, but not to stratum oriens horizontal interneurons, and that the natural pattern of activation of inhibitory and excitatory conductances during a synchronized burst cycle is different within the same neuronal population.
High-Frequency Oscillations in the Output Networks of the Hippocampal–Entorhinal Axis of the Freely Behaving Rat
TLDR
There is a powerful synchronization among the neuronal networks that connect the hippocampus to the neocortex during each hippocampal sharp wave, which biologically constrains theoretical models of hippocampal function and dysfunction and has the capacity to support an “off-line” memory consolidation process.
Input-Output Features of Anatomically Identified CA3 Neurons during Hippocampal Sharp Wave/Ripple Oscillation In Vitro
TLDR
The data support the hypothesis that the active current sources restricted to the stratum pyramidale during SWRs originate from the synaptic output of parvalbumin-expressing basket cells, which might explain their distinct recruitment to these synchronous events.
Perisomatic-targeting interneurons control the initiation of hippocampal population bursts
TLDR
This experiment showed that induced spiking activity of an individual perisomatic-targeting interneuron can both suppress and subsequently enhance local sharp wave generation, suggesting that interneurons may play an integral part in the local information processing that takes place in the hippocampus.
Lamina-specific contribution of glutamatergic and GABAergic potentials to hippocampal sharp wave-ripple complexes
TLDR
A complementary role of spatially confined excitatory and inhibitory transmission during highly ordered network patterns in the hippocampus is illustrated, which may be responsible for the precise timing of discharge probability during the time course of SPW-R.
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The principles of the authors' epileptic synchronization model apply even when slow inhibitory postsynaptic potentials are present, as apparently occurs in the epileptic hippocampal slice, because bursting can propagate through several generations in the network before slow inhibition builds up enough to block burst propagation.
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