Two-stage dynamic DNA quality check by xeroderma pigmentosum group C protein.

  title={Two-stage dynamic DNA quality check by xeroderma pigmentosum group C protein.},
  author={Ulrike Camenisch and Daniel Tr{\"a}utlein and F C Clement Clement and Jia Fei and Alfred Leitenstorfer and Elisa Ferrando-May and Hanspeter Naegeli},
  journal={The EMBO journal},
  volume={28 16},
Xeroderma pigmentosum group C (XPC) protein initiates the DNA excision repair of helix-distorting base lesions. To understand how this versatile subunit searches for aberrant sites within the vast background of normal genomic DNA, the real-time redistribution of fluorescent fusion constructs was monitored after high-resolution DNA damage induction. Bidirectional truncation analyses disclosed a surprisingly short recognition hotspot, comprising approximately 15% of human XPC, that includes two… CONTINUE READING
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