Two-stage activation for alpha5beta1 integrin binding to surface-adsorbed fibronectin.

  title={Two-stage activation for alpha5beta1 integrin binding to surface-adsorbed fibronectin.},
  author={Andr{\'e}s J Garc{\'i}a and Junichi Takagi and David Boettiger},
  journal={The Journal of biological chemistry},
  volume={273 52},
By analyzing the functional binding of alpha5beta1 integrin to adsorbed fibronectin in intact cells, we demonstrate that integrin activation results in linear increases in adhesion strength as a function of ligand density, suggesting that modulation of the receptor-ligand interaction is the dominant mechanism for adhesion during the initial stages of adhesion and that cooperative binding contributes little to initial adhesion strength. Using this experimental framework, we show the existence of… CONTINUE READING

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