Two stacked heme molecules in the binding pocket of the periplasmic heme-binding protein HmuT from Yersinia pestis.

@article{Mattle2010TwoSH,
  title={Two stacked heme molecules in the binding pocket of the periplasmic heme-binding protein HmuT from Yersinia pestis.},
  author={Daniel Mattle and Antra Zelti{\~n}a and Jae-Sung Woo and Birke A. Goetz and Kaspar P Locher},
  journal={Journal of molecular biology},
  year={2010},
  volume={404 2},
  pages={
          220-31
        }
}
The periplasmic binding protein HmuT from Yersinia pestis (YpHmuT) is a component of the heme uptake locus hmu and delivers bound hemin to the inner-membrane-localized, ATP-binding cassette (ABC) transporter HmuUV for translocation into the cytoplasm. The mechanism of this process, heme transport across the inner membrane of pathogenic bacteria, is currently insufficiently understood at the molecular level. Here we describe the crystal structures of the substrate-free and heme-bound states of… CONTINUE READING

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