Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities.

@article{Itallie2006TwoSV,
  title={Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities.},
  author={Christina M Van Itallie and Sarah C Rogan and A. C. Yu and Lucia Seminario Vidal and Jennifer G Holmes and James Melvin Anderson},
  journal={American journal of physiology. Renal physiology},
  year={2006},
  volume={291 6},
  pages={F1288-99}
}
Members of the large claudin family of tight junction (TJ) proteins create the differences in paracellular conductance and charge selectivity observed among different epithelia. Previous studies demonstrated that ionic charge selectivity is influenced by acidic or basic amino acids on the first extracellular domain of claudins. We noted two alternatively spliced variants of claudin-10 in the database, 10a and 10b, which are predicted to encode two different first extracellular domains and asked… CONTINUE READING
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